Tyrants and free cities in the fourteenth century treated the clergy at times with such sovereign contempt that very different matters from natural science went unpunished. But when, with the fifteenth century, antiquity became the leading power in Italy, the breach it made in the old system was turned to account by every branch of secular science. Humanism, nevertheless, attracted to itself the best strength of the nation, and thereby, no doubt, did injury to the inductive investigation of nature. Here and there the Inquisition suddenly started into life, and punished or burned physicians as blasphemers or magicians. In such cases it is hard to discover what was the true motive underlying the condemnation. But even so, Italy, at the close of the fifteenth century, with Paolo Toscanelli, Luca Pacioli and Leonardo da Vinci, held incomparably the highest place among European nations in mathematics and the natural sciences, and the learned men of every country, even Regiomontanus and Copernicus, confessed themselves its pupils. This glory survived the Counter-reformation, and even today the Italians would occupy the first place in this respect if circumstances had not made it impossible for the greatest minds to devote themselves to tranquil research.