In the nature of the father, ambition, avarice, and sensuality were combined with strong and brilliant qualities. All the pleasures of power and luxury he granted himself from the first day of his pontificate in the fullest measure. In the choice of means to this end he was wholly without scruple; it was known at once that he would more than compensate himself for the sacrifices which his election had involved, and that the seller would far exceed the simony of the buyer. It must be remembered that the vice-chancellorship and other offices which Alexander had formerly held had taught him to know better and turn to more practical account the various sources of revenue than any other member of the Curia. As early as 1494, a Carmelite, Adam of Genoa, who had preached at Rome against simony, was found murdered in his bed with twenty wounds. Hardly a single cardinal was appointed without the payment of enormous sums of money.
But when the Pope in course of time fell under the influence of his son Cesare Borgia, his violent measures assumed that character of devilish wickedness which necessarily reacts upon the ends pursued. What was done in the struggle with the Roman nobles and with the tyrants of Romagna exceeded in faithlessness and barbarity even that measure to which the Aragonese rulers of Naples had already accustomed the world; and the genius for deception was also greater. The manner in which Cesare isolated his father, murdering brother, brother-in-law, and other relations or courtiers, whenever their favour with the Pope or their position in any other respect became inconvenient to him, is literally appalling. Alexander was forced to acquiesce in the murder of his best-loved son, the Duke of Gandia, since he himself lived in hourly dread of Cesare.