In addition to the historical-geographical value, the work of Cosmas is also of great artistic value because of the numerous pictures (miniatures) which adorn his text. It is likely that some of these pictures were the work of the author himself. The original manuscript of the sixth century has not survived, but the later manuscripts of The Christian Topography contain copies of the original miniatures and thus serve as a valuable source for the history of early Byzantine, especially Alexandrine, art. The miniatures in the work of Cosmas, said N. P. Kondakov, are more characteristic of Byzantine art of the period of Justinian, or rather of the brilliant part of his reign, than any other monument of that period, except some of the mosaics at Ravenna.
The work of Cosmas was later translated into Slavonic and became widely spread among the Slavs. There exist numerous Russian versions of The Christian Topography supplemented with the portrait of Cosmas Indicopleustes and numerous pictures and miniatures which are of much interest in the history of old Russian art.